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A var gene promoter implicated in severe malaria nucleates silencing and is regulated by 3’ untranslated region and intronic cis-elements

Questions surround the mechanism of mutually exclusive expression by which Plasmodium falciparum mediates activation and silencing of var genes. These encode PfEMP1 proteins, which function as cytoadherent and immunomodulatory molecules at the surface of parasitized erythrocytes. Current evidence su...

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Main Authors: Muhle, Rebecca A., Adjalley, Sophie, Falkard, Brie, Nkrumah, Louis J., Muhle, Michael E., Fidock, David A.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744600/
https://ncbi.nlm.nih.gov/pubmed/19463825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpara.2009.05.001
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