Mucosal immunization in macaques upregulates the innate APOBEC 3G antiviral factor in CD4(+) memory T cells

APOBEC3G is an innate intracellular anti-viral factor which deaminates retroviral cytidine to uridine. In vivo studies of APOBEC3G (A3G) were carried out in rhesus macaques, following mucosal immunization with SIV antigens and CCR5 peptides, linked to the 70kD heat shock protein. A progressive incre...

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Detalhes bibliográficos
Main Authors: Wang, Yufei, Bergmeier, Lesley A., Stebbings, Richard, Seidl, Thomas, Whittall, Trevor, Singh, Mahavir, Berry, Neil, Almond, Neil, Lehner, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744409/
https://ncbi.nlm.nih.gov/pubmed/19084567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.11.084
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