A Splice Variant of ASC Regulates IL-1β Release and Aggregates Differently from Intact ASC

The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recrui...

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Bibliographic Details
Main Authors: Matsushita, Kazuhiko, Takeoka, Michiko, Sagara, Junji, Itano, Naoki, Kurose, Yuka, Nakamura, Akihiro, Taniguchi, Shun'ichiro
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744265/
https://ncbi.nlm.nih.gov/pubmed/19759850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/287387
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