Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome

Mechanisms of action of non-mutagenic carcinogens such as asbestos remain poorly characterized. As pleural mesothelioma is known to have limited numbers of genetic mutations, we aimed to characterize the relationships among gene-locus specific methylation alterations, disease status, asbestos burden...

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Autori principali: Christensen, Brock C., Houseman, E.A., Godleski, John J., Marsit, Carmen J., Longacker, Jennifer L., Roelofs, Cora R., Karagas, Margaret R., Wrensch, Margaret R., Yeh, Ru-Fang, Nelson, Heather H., Wiemels, Joe L., Zheng, Shichun, Wiencke, John K., Bueno, Raphael, Sugarbaker, David J., Kelsey, Karl T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744125/
https://ncbi.nlm.nih.gov/pubmed/19118007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2586
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