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Radiotherapy Combined with Intratumoral Dendritic Cell Vaccination Enhances the Therapeutic Efficacy of Adoptive T-Cell Transfer

Treatment of C57BL/6 mice with cyclophosphamide (100 mg/kg) and fludarabine (200 mg/kg) induced non-myeloablative lymphodepletion without inhibiting D5 melanoma tumor growth. Utilizing this model, we found that induction of lymphopenia prior to adoptive transfer of ex vivo anti-CD3/CD28 activated an...

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Detalhes bibliográficos
Main Authors: Teitz-Tennenbaum, Seagal, Li, Qiao, Davis, Mary A., Wilder-Romans, Kari, Hoff, Janet, Li, Mu, Chang, Alfred E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743975/
https://ncbi.nlm.nih.gov/pubmed/19483649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181a95165
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