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The Bcl-2 Antagonist HA14-1 Forms a Fluorescent Albumin Complex that Can Be Mistaken for Several Oxidized ROS Probes

The proapoptotic effects of the Bcl-2 antagonist HA14-1 are believed to derive from its affinity for the hydrophobic groove on Bcl-2 and Bcl-x(L), thereby displacing proapoptotic factors, e.g. Bax and Bak. We have reported that HA14-1 promotes the efficacy of low-dose photodynamic therapy (PDT). A r...

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Autori principali: Kessel, David, Price, Michael, Reiners, John J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743960/
https://ncbi.nlm.nih.gov/pubmed/18513234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1751-1097.2008.00371.x
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