sickle, a Novel Drosophila Death Gene in the reaper/hid/grim Region, Encodes an IAP-Inhibitory Protein

Inhibitors of apoptosis proteins (IAPs) interact with caspases and inhibit their protease activity, whereas the IAP-inhibitory proteins Smac/DIABLO in mammals and Reaper, Hid, and Grim in flies relieve IAP-mediated inhibition [1-5] to induce cell death. Here we describe the functional characterizati...

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Autori principali: Srinivasula, Srinivasa M., Datta, Pinaki, Kobayashi, Masatomo, Wu, Jia-Wei, Fujioka, Miki, Hegde, Ramesh, Zhang, ZhiJia, Mukattash, Rula, Fernandes-Alnemri, Teresa, Shi, Yigong, Jaynes, James B., Alnemri, Emad S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2002
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743937/
https://ncbi.nlm.nih.gov/pubmed/11818063
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