Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling

Alternative splicing of ASI residues (Ala(3481)-Gln(3485)) in the skeletal muscle ryanodine receptor (RyR1) is developmentally regulated: the residues are present in adult ASI(+)RyR1, but absent in the juvenile ASI(-)RyR1 which is over-expressed in adult myotonic dystrophy type 1 (DM1). Although thi...

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Bibliographic Details
Main Authors:	Kimura, Takashi, Lueck, John D., Harvey, Peta J., Pace, Suzy M., Ikemoto, Noriaki, Casarotto, Marco G., Dirksen, Robert T., Dulhunty, Angela F.
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2743929/ https://ncbi.nlm.nih.gov/pubmed/19131108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2008.11.005
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Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling

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