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The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters

Hepcidin, the principal regulator of the iron metabolism, is up-regulated in response to inflammatory stimuli, bone morphogenic proteins (BMPs), and iron excess. There are two murine hepcidin genes: hepcidin-1 (Hamp1) and hepcidin-2 (Hamp2). Hamp1 gene responds to both IL-6 and BMPs while Hamp2 resp...

詳細記述

保存先:
書誌詳細
主要な著者: Truksa, Jaroslav, Lee, Pauline, Beutler, Ernest
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743926/
https://ncbi.nlm.nih.gov/pubmed/17689119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2007.06.014
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