Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

BACKGROUND AND PURPOSE: TAK-242, a novel synthetic small-molecule, suppresses production of multiple cytokines by inhibiting Toll-like receptor (TLR) 4 signalling. In this study, we investigated the target molecule of TAK-242 and examined its therapeutic effect in a mouse sepsis model. EXPERIMENTAL...

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Main Authors: Takashima, K, Matsunaga, N, Yoshimatsu, M, Hazeki, K, Kaisho, T, Uekata, M, Hazeki, O, Akira, S, Iizawa, Y, Ii, M
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743844/
https://ncbi.nlm.nih.gov/pubmed/19563534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00297.x
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