Susceptibility locus in neurokinin-1 receptor gene associated with alcohol dependence

Substance P (SP), a neurotransmitter in stress pathways, exerts its effects mainly through the neurokinin-1 receptor (NK1R). Genetic and pharmacologic studies show that binding of ligands to NK1R decreases anxiety-related behaviors and therefore self-administration of alcohol in mice and craving for...

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Detalhes bibliográficos
Main Authors: Seneviratne, Chamindi, Ait-Daoud, Nassima, Ma, Jennie Z., Chen, Guobo, Johnson, Bankole A., Li, Ming D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743763/
https://ncbi.nlm.nih.gov/pubmed/19553914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.65
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