Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? An evidence-based review

This evidence-based review addresses the question of whether testing for UGT1A1 mutations in patients with metastatic colorectal cancer treated with irinotecan leads to improvement in outcomes (e.g., irinotecan toxicity, response to treatment, morbidity, and mortality), when compared with no testing...

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Autori principali: Palomaki, Glenn E., Bradley, Linda A., Douglas, Michael P., Kolor, Katherine, Dotson, W. David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American College of Medical Genetics 2009
Soggetti:
Evidence Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743611/
https://ncbi.nlm.nih.gov/pubmed/19125129
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