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Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ
The nuclear receptors REV-ERBα (encoded by NR1D1) and REV-ERBβ (NR1D2) have remained orphans owing to the lack of identified physiological ligands. Here we show that heme is a physiological ligand of both receptors. Heme associates with the ligand-binding domains of the REV-ERB receptors with a 1:1...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743565/ https://ncbi.nlm.nih.gov/pubmed/18037887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1344 |
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