Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ

The nuclear receptors REV-ERBα (encoded by NR1D1) and REV-ERBβ (NR1D2) have remained orphans owing to the lack of identified physiological ligands. Here we show that heme is a physiological ligand of both receptors. Heme associates with the ligand-binding domains of the REV-ERB receptors with a 1:1...

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Autores principales: Raghuram, Srilatha, Stayrook, Keith R, Huang, Pengxiang, Rogers, Pamela M, Nosie, Amanda K, McClure, Don B, Burris, Lorri L, Khorasanizadeh, Sepideh, Burris, Thomas P, Rastinejad, Fraydoon
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743565/
https://ncbi.nlm.nih.gov/pubmed/18037887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1344
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