Thrombin Inhibition By Argatroban Ameliorates Early Brain Injury And Improves Neurological Outcomes After Experimental Subarachnoid Hemorrhage In Rat

BACKGROUND AND PURPOSE: We investigated the role of thrombin in early brain injury after subarachnoid hemorrhage (SAH). METHODS: The standard intravascular perforation model was used to produce experimental SAH in Sprague Dawley rats. Low dose (0.3mg/hr) and high dose (0.3mg/hr) of argatroban, a dir...

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Hlavní autoři: Sugawara, Takashi, Jadhav, Vikram, Ayer, Robert, Chen, Wanqiu, Suzuki, Hidenori, Zhang, John H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743552/
https://ncbi.nlm.nih.gov/pubmed/19228846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.108.531699
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