HOW A SINGLE-POINT MUTATION IN HORSERADISH PEROXIDASE MARKEDLY ENHANCES ENANTIOSELECTIVITY

The effect of all possible mutations at position 178 on the enantioselectivity of yeast surface-bound horseradish peroxidase (HRP) toward chiral phenols has been investigated. In contrast to their wild-type predecessor, most HRP mutants are enantioselective, with the Arg178Glu variant exhibiting the...

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Hlavní autoři: Antipov, Eugene, Cho, Art E., Klibanov, Alexander M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743472/
https://ncbi.nlm.nih.gov/pubmed/19610634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja903482u
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