Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas

The O(6)-methylguanine-DNA methyltransferase gene (MGMT) is methylated in several cancers, including gliomas. However, the functional role of cysteine-phosphate-guanine (CpG) island (CGI) methylation in MGMT silencing is still controversial. The aim of this study was to investigate whether MGMT CGI...

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Detalhes bibliográficos
Main Authors: Everhard, Sibille, Tost, Jörg, Abdalaoui, Hafida El, Crinière, Emmanuelle, Busato, Florence, Marie, Yannick, Gut, Ivo G., Sanson, Marc, Mokhtari, Karima, Laigle-Donadey, Florence, Hoang-Xuan, Khê, Delattre, Jean-Yves, Thillet, Joëlle
Formato: Artigo
Idioma:Inglês
Publicado em: Duke University Press 2009
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743215/
https://ncbi.nlm.nih.gov/pubmed/19224763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2009-001
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