CD40L disruption enhances Aβ vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation

Amyloid-β (Aβ) immunization efficiently reduces amyloid plaque load and memory impairment in transgenic mouse models of Alzheimer’s disease (AD) (Schenk et al., 1999; Morgan et al., 2000). Active Aβ immunization has also yielded favorable results in a subset of AD patients (Hock et al., 2003). Howev...

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Main Authors: Obregon, D., Hou, H., Bai, Y., Nikolic, W.V., Mori, T., Luo, Deyan, Zeng, J., Ehrhart, J., Fernandez, F., Morgan, D., Giunta, B., Town, T., Tan, J.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743124/
https://ncbi.nlm.nih.gov/pubmed/18055209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.09.009
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