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Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability
Fenretinide (4HPR), a nontoxic analog of ATRA, has been investigated in various malignancies but not in multiple myeloma (MM), a plasma cell malignancy associated with induction of osteolytic bone disease. Here we show that 4HPR induces apoptosis through increased level of ROS and activation of casp...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743080/ https://ncbi.nlm.nih.gov/pubmed/19446953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2009.04.022 |
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