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Loss of rRNA modifications in the decoding center of the ribosome impairs translation and strongly delays pre-rRNA processing
The ribosome decoding center is rich in modified rRNA nucleotides and little is known about their effects. Here, we examine the consequences of systematically deleting eight pseudouridine and 2′-O-methylation modifications in the yeast decoding center. Loss of most modifications individually has no...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory Press
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743053/ https://ncbi.nlm.nih.gov/pubmed/19628622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1724409 |
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