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Loss of rRNA modifications in the decoding center of the ribosome impairs translation and strongly delays pre-rRNA processing

The ribosome decoding center is rich in modified rRNA nucleotides and little is known about their effects. Here, we examine the consequences of systematically deleting eight pseudouridine and 2′-O-methylation modifications in the yeast decoding center. Loss of most modifications individually has no...

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Bibliografski detalji
Glavni autori: Liang, Xue-hai, Liu, Qing, Fournier, Maurille J.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743053/
https://ncbi.nlm.nih.gov/pubmed/19628622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1724409
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