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Loss of rRNA modifications in the decoding center of the ribosome impairs translation and strongly delays pre-rRNA processing

The ribosome decoding center is rich in modified rRNA nucleotides and little is known about their effects. Here, we examine the consequences of systematically deleting eight pseudouridine and 2′-O-methylation modifications in the yeast decoding center. Loss of most modifications individually has no...

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Bibliografiska uppgifter
Huvudupphovsmän: Liang, Xue-hai, Liu, Qing, Fournier, Maurille J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743053/
https://ncbi.nlm.nih.gov/pubmed/19628622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1724409
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