WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis

Metastasis from lung adenocarcinoma can occur swiftly to multiple organs within months of diagnosis. The mechanisms that confer this rapid metastatic capacity to lung tumors are unknown. Activation of the canonical WNT/TCF pathway is identified here as a determinant of metastasis to brain and bone d...

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Autors principals: Nguyen, Don X., Chiang, Anne C., Zhang, Xiang H.F., Kim, Juliet Y., Kris, Mark G., Ladanyi, Marc, Gerald, William L., Massagué, Joan
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742946/
https://ncbi.nlm.nih.gov/pubmed/19576624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.04.030
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