Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear β-catenin in cerebral metastasis of lung adenocarcinomas

An essential function of the transcription factors LEF1/TCF4 in cerebral metastases of lung adenocarcinomas has been described in mouse models, suggesting a WNT/β-catenin effect as potential mechanism. Their role in humans is still unclear, thus we analyzed LEF1, TCF4, β-catenin, and early stage pro...

Full description

Saved in:
Bibliographic Details
Main Authors: Bleckmann, A., Siam, L., Klemm, F., Rietkötter, E., Wegner, Chr., Kramer, F., Beissbarth, T., Binder, C., Stadelmann, Chr., Pukrop, T.
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2012
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616220/
https://ncbi.nlm.nih.gov/pubmed/23224985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10585-012-9552-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items