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Essential Role of Cofilin-1 in Regulating Thrombin-induced RelA/p65 Nuclear Translocation and Intercellular Adhesion Molecule 1 (ICAM-1) Expression in Endothelial Cells

Activation of RhoA/Rho-associated kinase (ROCK) pathway and the associated changes in actin cytoskeleton induced by thrombin are crucial for activation of NF-κB and expression of its target gene ICAM-1 in endothelial cells. However, the events acting downstream of RhoA/ROCK to mediate these response...

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Bibliografiske detaljer
Main Authors: Fazal, Fabeha, Bijli, Kaiser M., Minhajuddin, Mohd, Rein, Theo, Finkelstein, Jacob N., Rahman, Arshad
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742869/
https://ncbi.nlm.nih.gov/pubmed/19483084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016444
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