Protein Kinase C-δ and Phosphatidylinositol 3-Kinase/Akt Activate Mammalian Target of Rapamycin to Modulate NF-κB Activation and Intercellular Adhesion Molecule-1 (ICAM-1) Expression in Endothelial Cells

We have shown that the mammalian target of rapamycin (mTOR) down-regulates thrombin-induced ICAM-1 expression in endothelial cells by suppressing the activation of NF-κB. However, the mechanisms by which mTOR is activated to modulate these responses remain to be addressed. Here, we show that thrombi...

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Détails bibliographiques
Auteurs principaux: Minhajuddin, Mohd, Bijli, Kaiser M., Fazal, Fabeha, Sassano, Antonella, Nakayama, Keiichi I., Hay, Nissim, Platanias, Leonidas C., Rahman, Arshad
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Mechanisms of Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640976/
https://ncbi.nlm.nih.gov/pubmed/19074768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805032200
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