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Converse Conformational Control of Smoothened Activity by Structurally Related Small Molecules
The seven-pass transmembrane protein Smoothened (Smo) is an essential component of the Hedgehog (Hh) signaling pathway that is critically involved in normal animal development as well as pathological malignancies. In studying Hh-related biological processes, it would be highly desirable if Smo activ...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2742853/ https://ncbi.nlm.nih.gov/pubmed/19366682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807648200 |
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