Converse Conformational Control of Smoothened Activity by Structurally Related Small Molecules

The seven-pass transmembrane protein Smoothened (Smo) is an essential component of the Hedgehog (Hh) signaling pathway that is critically involved in normal animal development as well as pathological malignancies. In studying Hh-related biological processes, it would be highly desirable if Smo activ...

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Autors principals: Yang, Hongbo, Xiang, Jing, Wang, Nengdong, Zhao, Yun, Hyman, Joel, Li, Song, Jiang, Jin, Chen, James K., Yang, Zhen, Lin, Shuo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742853/
https://ncbi.nlm.nih.gov/pubmed/19366682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807648200
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