Determination of Key Residues for Catalysis and RNA Cleavage Specificity: ONE MUTATION TURNS RNase II INTO A “SUPER-ENZYME”

RNase II is the prototype of a ubiquitous family of enzymes that are crucial for RNA metabolism. In Escherichia coli this protein is a single-stranded-specific 3′-exoribonuclease with a modular organization of four functional domains. In eukaryotes, the RNase II homologue Rrp44 (also known as Dis3)...

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Hlavní autoři: Barbas, Ana, Matos, Rute G., Amblar, Mónica, López-Viñas, Eduardo, Gomez-Puertas, Paulino, Arraiano, Cecília M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Transcription, Chromatin, and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742813/
https://ncbi.nlm.nih.gov/pubmed/19458082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.020693
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