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Determination of Key Residues for Catalysis and RNA Cleavage Specificity: ONE MUTATION TURNS RNase II INTO A “SUPER-ENZYME”
RNase II is the prototype of a ubiquitous family of enzymes that are crucial for RNA metabolism. In Escherichia coli this protein is a single-stranded-specific 3′-exoribonuclease with a modular organization of four functional domains. In eukaryotes, the RNase II homologue Rrp44 (also known as Dis3)...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2742813/ https://ncbi.nlm.nih.gov/pubmed/19458082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.020693 |
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