Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus

Therapeutic retroviral vector integration near the oncogene LMO2 is thought to be a cause of leukemia in X-SCID gene therapy trials. However, no published studies have evaluated the frequency of vector integrations near exon 1 of the LMO2 locus. We identified a high incidence region (HIR) of vector...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yamada, Koichiro, Tsukahara, Tomonori, Yoshino, Kazuhisa, Kojima, Katsuhiko, Agawa, Hideyuki, Yamashita, Yuki, Amano, Yuji, Hatta, Mariko, Matsuzaki, Yasunori, Kurotori, Naoki, Wakui, Keiko, Fukushima, Yoshimitsu, Osada, Ryosuke, Shiozawa, Tanri, Sakashita, Kazuo, Koike, Kenichi, Kumaki, Satoru, Tanaka, Nobuyuki, Takeshita, Toshikazu
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2009
Sujets:
Short Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742512/
https://ncbi.nlm.nih.gov/pubmed/19725963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-79
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