FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity

Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 × 10(-8)), microscopic polyangiitis (P...

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Autores principales: Fanciulli, Manuela, Norsworthy, Penny J, Petretto, Enrico, Dong, Rong, Harper, Lorraine, Kamesh, Lavanya, Heward, Joanne M, Gough, Stephen C L, de Smith, Adam, Blakemore, Alexandra I F, Froguel, Philippe, Owen, Catherine J, Pearce, Simon H S, Teixeira, Luis, Guillevin, Loic, Graham, Deborah S Cunninghame, Pusey, Charles D, Cook, H Terence, Vyse, Timothy J, Aitman, Timothy J
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742197/
https://ncbi.nlm.nih.gov/pubmed/17529978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng2046
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