IL-10 Suppresses Calcium-mediated Costimulation of RANK Signaling During Human Osteoclast Differentiation by Inhibiting TREM-2 Expression

Induction of effective osteoclastogenesis by RANK requires costimulation by ITAM-coupled receptors. In humans, the TREM-2 ITAM-coupled receptor plays a key role in bone remodeling, as patients with TREM-2 mutations exhibit defective osteoclastogenesis and bone lesions. We have identified a new rapid...

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Bibliographische Detailangaben
Hauptverfasser: Park-Min, Kyung-Hyun, Ji, Jong-Dae, Antoniv, Taras, Reid, Alicia C., Silver, Randi B., Humphrey, Mary Beth, Nakamura, Mary, Ivashkiv, Lionel B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742169/
https://ncbi.nlm.nih.gov/pubmed/19625651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804165
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