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Peripheral Neuropathy in Rats Exposed to Dichloroacetate

The use of dichloroacetate (DCA) for treating patients with mitochondrial diseases is limited by the induction of peripheral neuropathy. The mechanisms of DCA-induced neuropathy are not known. Oral DCA treatment (50–500 mg/kg/day for up to 16 weeks) induced tactile allodynia in both juvenile and adu...

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Detalhes bibliográficos
Main Authors: Calcutt, Nigel A., Lopez, Veronica L., Bautista, Arjel D., Mizisin, Leah M., Torres, Brenda R., Shroads, Albert L., Mizisin, Andrew P., Stacpoole, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741559/
https://ncbi.nlm.nih.gov/pubmed/19680144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3181b40217
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