Combined genome-wide expression profiling and targeted RNA interference in primary mouse macrophages reveals perturbation of transcriptional networks associated with interferon signalling

BACKGROUND: Interferons (IFNs) are potent antiviral cytokines capable of reprogramming the macrophage phenotype through the induction of interferon-stimulated genes (ISGs). Here we have used targeted RNA interference to suppress the expression of a number of key genes associated with IFN signalling...

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Bibliografiske detaljer
Main Authors: Lacaze, Paul, Raza, Sobia, Sing, Garwin, Page, David, Forster, Thorsten, Storm, Petter, Craigon, Marie, Awad, Tarif, Ghazal, Peter, Freeman, Tom C
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741489/
https://ncbi.nlm.nih.gov/pubmed/19664281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-10-372
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