The single-chain immunotoxin MCSP-ETA’, targeting melanoma-associated chondroitin sulfate proteoglycan, is a potent inducer of apoptosis in cultured human melanoma cells

A recombinant immunotoxin was constructed by fusing a single-chain Fv (scFv) antibody fragment, specific for the melanoma-associated chondroitin sulfate proteoglycan (MCSP), to a truncated variant of Pseudomonas Exotoxin A (ETA’), carrying a C-terminal KDEL peptide for improved intracellular transpo...

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Détails bibliographiques
Auteurs principaux: Schwenkert, Michael, Birkholz, Katrin, Schwemmlein, Michael, Kellner, Christian, Peipp, Matthias, Nettelbeck, Dirk M., Schuler-Thurner, Beatrice, Schaft, Niels, Dörrie, Jan, Ferrone, Soldano, Kämpgen, Eckhart, Fey, Georg H.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741307/
https://ncbi.nlm.nih.gov/pubmed/18337643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0b013e3282f7c8f9
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