The single-chain immunotoxin MCSP-ETA’, targeting melanoma-associated chondroitin sulfate proteoglycan, is a potent inducer of apoptosis in cultured human melanoma cells

A recombinant immunotoxin was constructed by fusing a single-chain Fv (scFv) antibody fragment, specific for the melanoma-associated chondroitin sulfate proteoglycan (MCSP), to a truncated variant of Pseudomonas Exotoxin A (ETA’), carrying a C-terminal KDEL peptide for improved intracellular transpo...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Schwenkert, Michael, Birkholz, Katrin, Schwemmlein, Michael, Kellner, Christian, Peipp, Matthias, Nettelbeck, Dirk M., Schuler-Thurner, Beatrice, Schaft, Niels, Dörrie, Jan, Ferrone, Soldano, Kämpgen, Eckhart, Fey, Georg H.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741307/
https://ncbi.nlm.nih.gov/pubmed/18337643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0b013e3282f7c8f9
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares