Paclitaxel induces nucleolar enlargement in dorsal root ganglion neurons in vivo reducing oxaliplatin toxicity

Paclitaxel and oxaliplatin are promising drugs for combination trials but both induce peripheral neurotoxicity. To investigate this toxicity, 10-week-old female Wistar rats were given single intraperitoneal doses of paclitaxel and oxaliplatin, alone or in combination. Neurotoxicity was assessed by L...

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Detaylı Bibliyografya
Asıl Yazarlar: Jamieson, S M F, Liu, J, Hsu, T, Baguley, B C, McKeage, M J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2003
Konular:
Experimental Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741119/
https://ncbi.nlm.nih.gov/pubmed/12799641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601012
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