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Quantitative Prediction of Fold Resistance for Inhibitors of EGFR
Clinical use of ATP-competitive inhibitors of the epidermal growth factor receptor (EGFR) kinase domain can lead to an acquired drug resistant mutant L858R&T790M which dramatically reduces binding affinity relative to a prevalent cancer causing mutation L858R. In this study, we have used molecul...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2741091/ https://ncbi.nlm.nih.gov/pubmed/19627157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900729a |
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