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Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage

Subarachnoid hemorrhage (SAH) causes secondary brain injury due to vasospasm and inflammation. Here, we studied a rat model of mild-to-moderate SAH intended to minimize ischemia/hypoxia to examine the role of sulfonylurea receptor 1 (SUR1) in the inflammatory response induced by SAH. mRNA for Abcc8,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Simard, J Marc, Geng, Zhihua, Woo, S Kyoon, Ivanova, Svetlana, Tosun, Cigdem, Melnichenko, Ludmila, Gerzanich, Volodymyr
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740919/
https://ncbi.nlm.nih.gov/pubmed/18854840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2008.120
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