Crossing species barrier by PrP(Sc) replication in vitro generates new infectious prions

Prions are unconventional infectious agents composed exclusively by the misfolded prion protein (PrP(Sc)), which transmits the disease by propagating its abnormal conformation to the cellular prion protein (PrP(C)). A key characteristic of prions is their species barrier, by which prions from one sp...

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Detaylı Bibliyografya
Asıl Yazarlar: Castilla, Joaquín, Gonzalez-Romero, Dennisse, Saá, Paula, Morales, Rodrigo, De Castro, Jorge, Soto, Claudio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740631/
https://ncbi.nlm.nih.gov/pubmed/18775309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.030
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