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Crossing species barrier by PrP(Sc) replication in vitro generates new infectious prions
Prions are unconventional infectious agents composed exclusively by the misfolded prion protein (PrP(Sc)), which transmits the disease by propagating its abnormal conformation to the cellular prion protein (PrP(C)). A key characteristic of prions is their species barrier, by which prions from one sp...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2740631/ https://ncbi.nlm.nih.gov/pubmed/18775309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.030 |
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