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Crossing species barrier by PrP(Sc) replication in vitro generates new infectious prions
Prions are unconventional infectious agents composed exclusively by the misfolded prion protein (PrP(Sc)), which transmits the disease by propagating its abnormal conformation to the cellular prion protein (PrP(C)). A key characteristic of prions is their species barrier, by which prions from one sp...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2740631/ https://ncbi.nlm.nih.gov/pubmed/18775309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.030 |
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