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Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif

ERK3 and ERK4 are atypical MAPKs in which the canonical TXY motif within the activation loop of the classical MAPKs is replaced by SEG. Both ERK3 and ERK4 bind, translocate, and activate the MAPK-activated protein kinase (MK) 5. The classical MAPKs ERK1/2 and p38 interact with downstream MKs (RSK1–3...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Åberg, Espen, Torgersen, Knut Martin, Johansen, Bjarne, Keyse, Stephen M., Perander, Maria, Seternes, Ole-Morten
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740564/
https://ncbi.nlm.nih.gov/pubmed/19473979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023283
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