Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif

ERK3 and ERK4 are atypical MAPKs in which the canonical TXY motif within the activation loop of the classical MAPKs is replaced by SEG. Both ERK3 and ERK4 bind, translocate, and activate the MAPK-activated protein kinase (MK) 5. The classical MAPKs ERK1/2 and p38 interact with downstream MKs (RSK1–3...

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Detalhes bibliográficos
Main Authors: Åberg, Espen, Torgersen, Knut Martin, Johansen, Bjarne, Keyse, Stephen M., Perander, Maria, Seternes, Ole-Morten
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740564/
https://ncbi.nlm.nih.gov/pubmed/19473979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023283
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