Membrane Potential Greatly Enhances Superoxide Generation by the Cytochrome bc(1) Complex Reconstituted into Phospholipid Vesicles

The mitochondrial cytochrome bc(1) complex (ubiquinol/cytochrome c oxidoreductase) is generally thought to generate superoxide anion that participates in cell signaling and contributes to cellular damage in aging and degenerative disease. However, the isolated, detergent-solubilized bc(1) complex do...

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Bibliographic Details
Main Authors: Rottenberg, Hagai, Covian, Raul, Trumpower, Bernard L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Metabolism and Bioenergetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740544/
https://ncbi.nlm.nih.gov/pubmed/19478336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.017376
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