Kynurenic Acid Triggers Firm Arrest of Leukocytes to Vascular Endothelium under Flow Conditions

Recent studies have demonstrated that kynurenic acid (KYNA), a compound produced endogenously by the interferon-γ-induced degradation of tryptophan by indoleamine 2,3-dioxygenase, activates the previously orphaned G protein-coupled receptor, GPR35. This receptor is expressed in immune tissues, altho...

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Detalhes bibliográficos
Main Authors: Barth, Marita C., Ahluwalia, Neil, Anderson, Thomas J. T., Hardy, Gregory J., Sinha, Sumita, Alvarez-Cardona, Jose A., Pruitt, Ivy E., Rhee, Eugene P., Colvin, Richard A., Gerszten, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740542/
https://ncbi.nlm.nih.gov/pubmed/19473985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024042
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