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Determinants in Ca(V)1 Channels That Regulate the Ca(2+) Sensitivity of Bound Calmodulin
Calmodulin binds to IQ motifs in the α(1) subunit of Ca(V)1.1 and Ca(V)1.2, but the affinities of calmodulin for the motif and for Ca(2+) are higher when bound to Ca(V)1.2 IQ. The Ca(V)1.1 IQ and Ca(V)1.2 IQ sequences differ by four amino acids. We determined the structure of calmodulin bound to Ca(...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2740430/ https://ncbi.nlm.nih.gov/pubmed/19473981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013326 |
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