Determinants in Ca(V)1 Channels That Regulate the Ca(2+) Sensitivity of Bound Calmodulin

Calmodulin binds to IQ motifs in the α(1) subunit of Ca(V)1.1 and Ca(V)1.2, but the affinities of calmodulin for the motif and for Ca(2+) are higher when bound to Ca(V)1.2 IQ. The Ca(V)1.1 IQ and Ca(V)1.2 IQ sequences differ by four amino acids. We determined the structure of calmodulin bound to Ca(...

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Hauptverfasser: Halling, D. Brent, Georgiou, Dimitra K., Black, D. J., Yang, Guojun, Fallon, Jennifer L., Quiocho, Florante A., Pedersen, Steen E., Hamilton, Susan L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740430/
https://ncbi.nlm.nih.gov/pubmed/19473981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013326
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