S156C Mutation in Tissue Inhibitor of Metalloproteinases-3 Induces Increased Angiogenesis

Tissue Inhibitor of metalloproteinases-3 (TIMP-3) is a potent matrix-bound angiogenesis inhibitor. Mutations in TIMP-3 cause Sorsby Fundus Dystrophy, a dominant inherited, early onset macular degenerative disease, with choroidal neovascularization causing a loss of vision in the majority of patients...

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Bibliographic Details
Main Authors: Qi, Jian Hua, Dai, Ganying, Luthert, Philip, Chaurasia, Shyam, Hollyfield, Joe, Weber, Bernhard H. F., Stöhr, Heidi, Anand-Apte, Bela
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740418/
https://ncbi.nlm.nih.gov/pubmed/19478078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013763
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