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PD-1(+) memory phenotype CD4(+) T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia
Although altered T cell function plays a part in immunosenescence, the mechanisms remain uncertain. Here we identify a bona fide age-dependent PD-1(+) memory phenotype (MP) CD4(+) T cell subpopulation that hardly proliferates in response to T cell receptor (TCR) stimulation and produces abundant ost...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2739871/ https://ncbi.nlm.nih.gov/pubmed/19805226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908805106 |
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