Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

TBC1D1 is a Rab-GTPase-activating protein (GAP) known to be phosphorylated in response to insulin, growth factors, pharmacological agonists that activate 5′-AMP-activated protein kinase (AMPK), and muscle contraction. Silencing TBC1D1 in L6 muscle cells by siRNA increases insulin-stimulated GLUT4 tr...

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Main Authors: Pehmøller, Christian, Treebak, Jonas T., Birk, Jesper B., Chen, Shuai, MacKintosh, Carol, Hardie, D. Grahame, Richter, Erik A., Wojtaszewski, Jørgen F. P.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739697/
https://ncbi.nlm.nih.gov/pubmed/19531644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00115.2009
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