Disruption of the AMPK–TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion

Tre-2/USP6, BUB2, cdc16 domain family member 1 (the TBC domain is the GTPase activating protein domain) (TBC1D1) is a Rab GTPase activating protein that is phosphorylated on Ser(231) by the AMP-activated protein kinase (AMPK) in response to intracellular energy stress. However, the in vivo role and...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Chen, Liang, Chen, Qiaoli, Xie, Bingxian, Quan, Chao, Sheng, Yang, Zhu, Sangsang, Rong, Ping, Zhou, Shuilian, Sakamoto, Kei, MacKintosh, Carol, Wang, Hong Yu, Chen, Shuai
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932950/
https://ncbi.nlm.nih.gov/pubmed/27307439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600581113
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