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Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome
The proinflammatory cytokine IL-1β plays an important role in antifungal immunity; however the mechanisms by which fungal pathogens trigger IL-1β secretion are unclear. Here we show that infection with C. albicans is sensed by the Nlrp3 inflammasome resulting in the subsequent release of IL-1β. The...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2739101/ https://ncbi.nlm.nih.gov/pubmed/19684085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901323 |
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