The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

Myostatin is a member of the transforming growth factor-β (TGF-β) family and a strong negative regulator of muscle growth. Here, we present the crystal structure of myostatin in complex with the antagonist follistatin 288 (Fst288). We find that the prehelix region of myostatin very closely resembles...

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Bibliographic Details
Main Authors: Cash, Jennifer N, Rejon, Carlis A, McPherron, Alexandra C, Bernard, Daniel J, Thompson, Thomas B
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738701/
https://ncbi.nlm.nih.gov/pubmed/19644449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.205
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