Functional RET G691S Polymorphism in Cutaneous Malignant Melanoma

RET proto-oncogene encodes a receptor tyrosine kinase whose ligand is glial cell line-derived neurotrophic factor (GDNF), and its polymorphism at G691S juxtamembrane region (RETp) is a germline polymorphism. Cutaneous melanomas, particularly the desmoplastic subtype, are highly neurotropic; thus we...

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Autores principales: Narita, N, Tanemura, A, Murali, R, Scolyer, RA, Huang, S, Arigami, T, Yanagita, S, Chong, KK, Thompson, JF, Morton, DL, Hoon, DS
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738597/
https://ncbi.nlm.nih.gov/pubmed/19561646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.164
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